Which factor contributes to intolerance when using concentrated formulas?

Which factor contributes to intolerance when using concentrated formulas?

• A. Higher osmotic load
• B. Higher protein content
• C. Greater palatability
• D. Lower viscosity

Answer: (A)

The factor being tested is osmotic load. Concentrated formulas contain more solutes (glucose, electrolytes, amino acids) per unit volume, increasing their osmolarity. When such a high-osmolarity formula enters the GI tract, water is drawn into the lumen to balance the osmotic gradient, which can lead to diarrhea, cramping, nausea, and overall intolerance. Palatability isn’t a driver of intolerance for tube feeding, and higher protein content or viscosity don’t directly cause the osmotic-related intolerance seen with concentrated formulas. Lower viscosity would mainly affect administration ease, not the osmotic effect.

The factor being tested is osmotic load. Concentrated formulas contain more solutes (glucose, electrolytes, amino acids) per unit volume, increasing their osmolarity. When such a high-osmolarity formula enters the GI tract, water is drawn into the lumen to balance the osmotic gradient, which can lead to diarrhea, cramping, nausea, and overall intolerance. Palatability isn’t a driver of intolerance for tube feeding, and higher protein content or viscosity don’t directly cause the osmotic-related intolerance seen with concentrated formulas. Lower viscosity would mainly affect administration ease, not the osmotic effect.