Which are the two forms of glutamine dipeptides used in PN admixtures?

Which are the two forms of glutamine dipeptides used in PN admixtures?

• A. L-alanyl-L-glutamine
• B. Glycyl-L-glutamine
• C. L-alanyl-L-glutamine and Glycyl-L-glutamine
• D. None

Answer: (C)

Glutamine is added to parenteral nutrition as dipeptides to improve stability in IV solutions and ensure effective delivery. The two glutamine dipeptide forms commonly used in PN admixtures are L-alanyl-L-glutamine and glycyl-L-glutamine. These dipeptides are more stable and soluble than free glutamine, helping prevent degradation in the admixture; once in the body, they are cleaved by dipeptidases to release glutamine for use in tissues such as the gut and immune system. The option that reflects both forms is correct because each provides glutamine in a stable, deliverable form for PN.

Glutamine is added to parenteral nutrition as dipeptides to improve stability in IV solutions and ensure effective delivery. The two glutamine dipeptide forms commonly used in PN admixtures are L-alanyl-L-glutamine and glycyl-L-glutamine. These dipeptides are more stable and soluble than free glutamine, helping prevent degradation in the admixture; once in the body, they are cleaved by dipeptidases to release glutamine for use in tissues such as the gut and immune system. The option that reflects both forms is correct because each provides glutamine in a stable, deliverable form for PN.